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An Adolescent with Hyperimmunoglobulinemia D and Periodic Fever Syndrome Responding to Simvastatin Treatment. (Karakoc-Aydiner, Elif.)
Bibliographical information (record 266464)
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An Adolescent with Hyperimmunoglobulinemia D and Periodic Fever Syndrome Responding to Simvastatin Treatment.
Author:
 Karakoc-Aydiner, Elif. Search Author in Amazon Books

Publisher:
Turkish League Against Rheumatism,
Edition:
 2011.
Classification:
 WE 544
URL:
http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.5152/tjr.2011.026
Detailed notes
    - The hyperimmunoglobulinemia D and periodic fever syndrome is proposed to be caused by a defect in the activity of mevalonate kinase enzyme which is involved in cholesterol and non-sterol isoprenoid biosynthesis. This autosomal recessive inherited auto-inflammatory syndrome is characterized by recurrent fever attacks, abdominal pain, lymphadenopathy, skin lesions and joint involvement. In this article, we present our therapeutic approach with the hypolipidemic agent, simvastatin, in a 12-year-old boy followed up with a diagnosis of hyperimmunoglobulinemia D and periodic fever syndrome. Simvastatin treatment of an adolescent with hyperimmunoglobulinemia D and periodic fever syndrome unresponsive to anti-inflammatory strategies has resulted in a favorable outcome. This treatment is thought to reduce the recurrent fever attacks by reducing the mevalonic acid increase or isopreniod shortage.
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Status
Library
Section
EOL-1374
Item available
NEU Grand LibraryOnline (WE 544 .A5 2011)
Online electronic
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