NEU Grand Library | TRNC Library


	NEU GRAND LIBRARY Opening Hours: Monday-Saturday, 08:00-20:00 \| E-mail: library@neu.edu.tr

You are not logged in

Show Basket

Home

Advanced Search

Back

Add to Basket

Brief display

MARC Display

Reserve

Amitriptyline may have a supportive role in cancer treatment by inhibiting glutathione S-transferase pi (GST-pi) and alpha (GST-alpha) (Kulaksiz-Erkmen, Gulnihal.)

Bibliographical information (record 265907)

Amitriptyline may have a supportive role in cancer treatment by inhibiting glutathione S-transferase pi (GST-pi) and alpha (GST-alpha)
Author:	Kulaksiz-Erkmen, Gulnihal. Search Author in Amazon Books
Publisher:	Informa Healthcare,

Edition:	2013.
Classification:	QU4
URL:	http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3109/14756366.2011.639017

Detailed notes

- A tricyclic anti-depressant, amitriptyline, is a highly prescribed drug for cancer patients for mood elevation but there are limited studies about the interaction of amitriptyline with glutathione S-transferases pi (GST-pi) and glutathione S-transferases alpha (GST-alpha). GST isozymes have been implicated in chemotherapeutic drug resistance. We demonstrated that the concentration dependent inhibition of GST-pi and GST-alpha by amitriptyline followed inverse hyperbolic inhibition curves with IC50 values of 5.54 and 8.32 mM, respectively. When the varied substrate was GSH, amitriptyline inhibited both isozymes competitively and similar K-i values were found for GST-pi (K-i = 1.61 +/- 0.17 mM) and GST-alpha (K-i = 1.45 +/- 0.20 mM). On the other hand, when the varied substrate was CDNB, the inhibition types were non-competitive for GST-pi (K-i = 1.98 +/- 0.31 mM) and competitive for GST-alpha (K-i = 1.57 +/- 0.16 mM). Amitriptyline, in addition to its antidepressant effect, might also have a minor supportive role on the effectiveness of the anticancer drugs by decreasing their elimination through inhibiting GST-pi and GST-alpha.