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An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia
(Harman, Ferhat.) |
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Bibliographical information (record 265265) |
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An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia |
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Author:
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Harman, Ferhat.
 Search Author in Amazon Books
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Edition: |
2012.
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Classification: |
WL355 |
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- Objective: To study the effects of pre-ischemic hyperbaric
oxygen (HBO) and post-ischemic aminoguanidine (AG)
on the infarct volume in permanent middle cerebral
artery occlusion.
Methods: This study was approved by the Animal
Experiments Ethics Committee of Gulhane Military
Medical Academy, Ankara, Turkey and carried out from
March 2006 to August 2006. A total of 28 Sprague-
Dawley rats (200-320 g) were divided into 4 groups:
control (K) group (n = 7); HBO group (n = 7); HBO
+ AG group (n = 7); and the AG group (n = 7). All rats
underwent middle cerebral artery occlusion (MCAO)
by subtemporal craniectomy, and permanent ischemia
was created. A 2.8 atmospheric pressure of HBO was
first applied to the HBO and HBO + AG groups for
45 minutes, and occlusion was created after 2 hours. In
the HBO + AG group, intraperitoneal administration of
AG hemisulfate (100 mg/kg) was started 6 hours after
MCAO, and was continued twice a day for 3 days.
Results: The rate of infarction was found to be 22.2±3.1%
in the control group, 16.1±2.7% in the HBO group,
15.2±1.9% in the HBO+AG group, and 14.4±3.3%
in the AG groups. The rate of infarctions (therefore
the volume of infarct) in the HBO, HBO + AG, and
AG groups were found to be significantly decreased
compared with the control group (p=0.002, p=0.001,
and p=0.001).
Conclusion: In permanent MCAO-induced ischemia
in rats, HBO and AG were observed to have a lowering
effect on the infarct volume, but no additive effect was
observed. This situation can be explained by different
mechanisms of action.
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Barcode |
Status |
Library |
Section |
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EOL-768
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Item available
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NEU Grand LibraryOnline (WL355 .A5 2012)
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Online electronic |
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