a Record control number 000240458000008

a ISSN 1612-1872

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QD31.2

b Item number .A58 2006

a Personal name Çalış, İhsan,

h Medium Electronic Document

a Title Antitrypanosomal cycloartane glycosides from Astragalus baibutensis

c Statement of responsibility, etc Ihsan Calis, Semra Koyunoglu, Akgul Yesilada, Reto Brun, Peter Rueedi, Deniz Tasdemir.

c Date of publication, distribution, etc 2006.

b Name of publisher, distributor, etc Wiley-V C H Verlag Gmbh,

a Place of publication, distribution, etc Weinheim :

a Summary, etc Baibutoside (5), a new cycloartane-type triterpene glycoside, has been isolated from the roots of Astragalus baibutensis along with four known glycosides, acetylastragaloside 1 (1), and astragalosides 1, 11, and IV (2-4, resp.). The structure elucidation of the compounds were achieved by a combination of one- and two-dimensional NMR techniques (DQF-COSY, HSQC, HMBC, and ROESY), and mass spectrometry (ESI-MS), where all the compounds were shown to have cycloastragenol (=(20R,24S)-3 beta,6 alpha,16 beta,25-tetrahydroxy-20,24-epoxy-9,19-cyclolanostane) as aglycone. All compounds were tested for in vitro antiprotozoal activity. Compounds 1-4 displayed notable activity vs. Trypanosoma brucei rhodesiense, with acetylastragaloside 1 (1) being the most potent (IC50 9.5 mu g/ml). Acetylastragaloside I (1) was also lethal to T cruzi (IC50 5.0 mu g/ml), and it is the first cycloartane-type triterpene with remarkable trypanocidal activity against both T brucei rhodesiense and T cruzi. However, it exhibits some cytotoxicity on mammalian cells.

a Topical term or geographic name as entry element Chemistry

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Biochemistry & Molecular Biology

a Topical term or geographic name as entry element Triterpene Glycosides

a Topical term or geographic name as entry element Lymphocyte-Proliferation

g Relationship information 2006, Vol 3 Issue 8, p923-929

t Title Chemistry & Biodiversity

x International Standard Serial Number 16121872

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1002/cbdv.200690094